There are just two silly exceptions: antivirus software and stuff that's deeply embedded into the system needs updating - but the developers are on it already - and then there are old games on CD-Rom that have DRM. 'Everything that ran in Windows 7 should also run in Windows 10.
The video is in German, but in the segment at the timestamp linked above he says: This issue was touched upon by Microsoft's Boris Schneider-Johne at this year's Gamescom. For one, SafeDisc is notoriously insecure and Microsoft's decision to block it from their new operating system will likely protect more users than it hurts. Yet despite this change coming in Windows 10, blame can't likely be placed at Microsoft's feet. Games which used these forms of DRM range from Crimson Skies to Grand Theft Auto 3, Microsoft Flight Simulator 2004 to the original The Sims. Windows 10 won't run games that employ SafeDisc or certain versions of Securom DRM, rendering hundreds of old disc-based games potentially unplayable without complex workarounds.